Association between adiponectin gene polymorphisms and coronary artery disease across different populations
Thrombosis Research, 06/08/2012Zhou L et al.
The meta–analysis indicated the significant association of –11377C/G polymorphism, but not +45T/G or +276G/T polymorphism, with coronary artery disease (CAD) susceptibility. However, large–scale studies with the consideration of gene–gene and gene–environment interactions should be conducted to investigate the associations in future.
Published literature from PubMed and EMBASE databases were searched.
Pooled odds ratio (OR) and corresponding 95% confidence interval (CI) were calculated using fixed– or random–effects model.
Sixteen studies (4394 cases / 8187 controls) for +45T/G polymorphism, fifteen studies (3569 cases / 7463 controls) for +276G/T polymorphism, and thirteen studies (3531 cases / 7072 controls) for –11377C/G polymorphism were included in the meta–analysis.
The overall results showed that there was a statistically significant association between –11377C/G polymorphism and CAD (G vs. C: OR=1.15, 95%CI 1.07–1.24).
Similar results were observed among European (G vs. C: OR=1.11, 95%CI 1.02–1.20) and East Asian populations (G vs. C: OR=1.27, 95%CI 1.11–1.45).
However, no significant association was found for +45T/G or +276G/T polymorphism with CAD susceptibility.
MDLinx connects healthcare professionals and patients to tomorrow's important medical news, while providing the pharmaceutical and healthcare industries with highly targeted interactive marketing, education, content, and medical research solutions.