Association between adiponectin gene polymorphisms and coronary artery disease across different populations

Thrombosis Research, 06/08/2012

The meta–analysis indicated the significant association of –11377C/G polymorphism, but not +45T/G or +276G/T polymorphism, with coronary artery disease (CAD) susceptibility. However, large–scale studies with the consideration of gene–gene and gene–environment interactions should be conducted to investigate the associations in future.

Methods

  • Published literature from PubMed and EMBASE databases were searched.
  • Pooled odds ratio (OR) and corresponding 95% confidence interval (CI) were calculated using fixed– or random–effects model.

Results

  • Sixteen studies (4394 cases / 8187 controls) for +45T/G polymorphism, fifteen studies (3569 cases / 7463 controls) for +276G/T polymorphism, and thirteen studies (3531 cases / 7072 controls) for –11377C/G polymorphism were included in the meta–analysis.
  • The overall results showed that there was a statistically significant association between –11377C/G polymorphism and CAD (G vs. C: OR=1.15, 95%CI 1.07–1.24).
  • Similar results were observed among European (G vs. C: OR=1.11, 95%CI 1.02–1.20) and East Asian populations (G vs. C: OR=1.27, 95%CI 1.11–1.45).
  • However, no significant association was found for +45T/G or +276G/T polymorphism with CAD susceptibility.

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