Age at Onset and Vascular Pathology in Late-Life Depression
The American Journal of Geriatric Psychiatry, 06/01/2012Paranthaman R et al.
This study suggests that elderly subjects with late–onset depressed have greater vascular impairment than those with an early–onset illness.
Twenty-five subjects with late-life depression recruited from secondary care were divided into groups with EOD (<60 years, 11 subjects) and LOD (>60 years, 14 subjects).
All subjects underwent a variety of vascular assessments including pulse wave analysis, pulse wave velocity, carotid intima media thickness (IMT), and magnetic resonance imaging of the brain to assess white matter hyperintensities.
The mean age of LOD subjects was 71.3 ± 4.0 years and EOD was 73.6 ± 4.7 years (p = NS).
There were no baseline differences in vascular risk or sociodemographic variables.
LOD subjects had significantly higher common carotid IMT (EOD: 0.06 [0.01]; LOD: 0.09 [0.02], p = 0.02), carotid plaques (EOD: 2.1 [1.1]; LOD: 5.4 [3.9], p = 0.02), and peripheral augmentation index (EOD: 81.7 [7.9]; LOD: 96.2 [21.6], p = 0.04) when compared with early-onset subjects, indicating more vascular pathology.
There were no group differences in white matter hyperintensities.
Age at onset of depression was positively correlated with peripheral augmentation index, common carotid IMT, and plaque index.
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