Serum levels of RBP4 and adipose tissue levels of PTP1B are increased in obese men resident in northeast Scotland without associated changes in ER stress response genes

International Journal of General Medicine, 05/10/2012

Human obesity results in an increase in serum but not adipose tissue Retinol–binding protein 4 (RBP4) protein levels, and these are normalized in obese/diabetic subjects, which exhibit improvements in insulin sensitivity through diet or metformin treatment. However, while adipose tissue Protein tyrosine phosphatase 1B (PTP1B) mRNA levels increase in obese Scottish subjects, these remain high in obese/diabetics on diet or metformin treatment.

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