Effect on short- and long-term major adverse cardiac events of statin treatment in patients with acute myocardial infarction and renal dysfunction
The American Journal of Cardiology, 05/04/2012Lim SY et al.
Statin therapy reduced major adverse cardiac events (MACE) at 1 year of follow–up in patients with acute myocardial infarction (AMI) regardless of renal dysfunction (RD).
The 3–hydroxy–3–methylglutaryl–coenzyme A reductase inhibitors (statins) reduce major adverse cardiac events (MACE) and mortality in patients with acute coronary syndrome.
Authors investigated the effectiveness of statin therapy in reducing MACE in patients with acute myocardial infarction (AMI) and renal dysfunction (RD).
In the present retrospective study of 12,853 patients with AMI, the patients were categorized into 4 groups: group I, statin therapy and no RD (estimated glomerular filtration rate ≥60 ml/min/1.73 m2); group II, neither statin therapy nor RD; group III, statin therapy and RD; group IV, no statin therapy but RD.
The primary end points were death and complications during the hospital course.
The secondary end points were MACE during 1 year of follow–up after AMI.
Significant differences in the composite MACE during 12 months of follow–up were observed among the 4 groups (group I, 11.7%; group II, 19.0%; group III, 26.7%; and group IV, 45.5%; p <0.001).
In a Cox proportional hazards model, mortality at 12 months increased stepwise from group II to IV compared to group I.
Moreover, MACE–free survival in the severe RD group (estimated glomerular filtration rate <30 mL/min/1.73 m2) was also greater in the statin–treated group.
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