Intrathecal levels of vitamin D and IgG in multiple sclerosis

Acta Neurologica Scandinavica, 04/27/2012

Physiological variation in vitamin D does not exert a major impact on intrathecal synthesis of IgG in multiple sclerosis (MS).


  • To investigate the relation between vitamin D levels in cerebrospinal fluid and serum and intrathecal synthesis of IgG.
  • 25-hydroxyvitamin D (25(OH)D) and IgG were assessed in cerebrospinal fluid and serum in 40 patients with MS.


  • There was no significant correlation between the IgG index and 25(OH)D levels in cerebrospinal fluid or serum.
  • The levels of 25(OH)D in cerebrospinal fluid and serum did not differ between patients with and without intrathecal synthesis of IgG.
  • There was a non-significant trend towards a positive correlation between the concentrations of 25(OH)D and IgG in the cerebrospinal fluid, but not in serum.

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