Improvement of arterial stiffness by reducing oxidative stress damage in elderly hypertensive patients after 6 months of atorvastatin therapy

The Journal of Clinical Hypertension, 04/25/2012

These findings suggest that atorvastatin can improve arterial stiffness possibly by reducing oxidative stress levels in elderly hypertensive patients.

Methods

  • A total of 73 elderly hypertensive patients were enrolled to receive atorvastatin for 6 months.
  • Brachial–ankle pulse wave velocity (baPWV) and circulating biomarkers were measured before and after the intervention.

Results

  • After 6 months of treatment, the patients experienced a 19.66% reduction in low–density lipoprotein cholesterol (2.90±0.58 vs 2.33±0.56 mmol/L, P<.01) and a 10.63% reduction in baPWV (2100.89±513.21 vs 1877.56±432.06 cm/s, P=.01).
  • In addition, a 21.79% reduction in circulating N–(epsilon)–carboxymethyl–lysine and a 20% reduction in Von Willebrand factor level were observed after treatment.
  • Meanwhile, the activity of copper/zinc–containing superoxide dismutase (Cu/Zn SOD) was increased by 26.64% (5.04±1.01 vs 6.87±1.83 U/L, P<.001).
  • Correlation analysis demonstrated that the increase of Cu/Zn SOD activity was related to the reductions of arterial stiffness (r=–0.340, P=.003).

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