Clinical features and prognostic factors in patients with carcinomatous meningitis secondary to breast cancer

The Breast Journal, 04/24/2012

According to multivariate analysis, patients were divided into favorable and poor prognostic groups, with OS of 14 weeks and 2 weeks, respectively (p < .001). These factors can identify a subgroup of patients who are candidates for an intensive management approach.

Methods

  • The purpose of this study was to describe a series of patients with breast cancer–associated CM to determine the clinical features and prognostic factors associated with survival.
  • Authors conducted a retrospective study on 49 patients diagnosed between January 2003 and December 2007 at the Instituto Nacional de Cancerolog√≠a in Mexico City. CSF cytopathology samples were re–reviewed to confirm the diagnosis.

Results

  • Overall survival (OS) for patients with breast cancer with CM was 7 weeks.
  • Factors independently associated with better OS included absence of encephalopathy at diagnosis (11 weeks versus 1 week; p = .036), low CSF protein content (15 versus 5 weeks; p = .022), and nontriple–negative receptor status in the primary breast cancer tumor (13 versus 3 weeks; p = .015).

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