Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia

Gastroenterology, 04/20/2012

The authors show that more than 99% of the earliest–stage, lowest–grade, pancreatic intraepithelial neoplasm–1 lesions contain mutations in KRAS, p16/CDKN2A, GNAS, or BRAF. These findings could improve the understanding of the development and progression of these premalignant lesions.

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