Cognitive impairment and vitamin B12: a review

International Psychogeriatrics, 02/28/2012

Low serum vitamin B12 levels are associated with neurodegenerative disease and cognitive impairment. There is a small subset of dementias that are reversible with vitamin B12 therapy and this treatment is inexpensive and safe. Vitamin B12 therapy does not improve cognition in patients without pre–existing deficiency. There is a need for large, well–resourced clinical trials to close the gaps in the current understanding of the nature of the associations of vitamin B12 insufficiency and neurodegenerative disease.

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