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Carbonyl Reductase 1 Offers a Novel Therapeutic Target to Enhance Leukemia Treatment by Arsenic Trioxide

Jang M et al. – The findings indicate that carbonyl reductase 1 (CBR1) contributes to the low efficacy of Arsenic trioxide (As2O3) and, therefore, is a rational target for the development of combination chemotherapy with As2O3 in diverse leukemias including acute promyelocytic leukemia (APL). [more...]

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