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Immunogenicity and Cross-Reactivity of a Representative Ancestral Sequence in Hepatitis C Virus Infection

Burke KP et al. – CD8+ T cells expanded with representative sequence hepatitis C virus (HCV) generally more broadly and robustly recognized highly diverse circulating HCV strains than did T cells expanded with either consensus sequence or naturally occurring sequence variants. These data support the use of representative sequence in HCV vaccine design. [more...]

The Journal of Immunology

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