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Proteolytic activation of proapoptotic kinase protein kinase Cdelta by tumor necrosis factor alpha death receptor signaling in dopaminergic neurons during neuroinflammation

Gordon R et al. – The results identify proteolytic activation of protein kinase Cdelta (PKCdelta) proapoptotic signaling as a key downstream effector of dopaminergic cell death induced by Tumor necrosis factor alpha (TNF). These findings also provide a rationale for therapeutically targeting PKCdelta to mitigate progressive dopaminergic degeneration resulting from chronic neuroinflammatory processes. [more...]

Journal of Neuroinflammation

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