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Activation of nuclear factor-kappa B accelerates vascular calcification by inhibiting ankylosis protein homolog expression

Zhao G et al. – Both human calcified atherosclerotic lesions and arteries from patients with chronic kidney disease had activated nuclear factor–kappa B (NF–κB) and decreased ankylosis protein homolog expression. Thus, tumor necrosis factor (TNF)–activated NF–κB promotes inflammation–accelerated vascular calcification by inhibiting ankylosis protein homolog expression and consequent pyrophosphate secretion. [more...]

Kidney International

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