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See Latest ArticlesPRKCSH/80K-H, the protein mutated in polycystic liver disease, protects polycystin-2/TRPP2 against HERP-mediated degradation
Human Molecular Genetics, 12/15/09
Gao H et al. – The findings suggest that PRKCSH functions as a chaperone–like molecule, which prevents ERAD of TRPP2. Dysequilibrium between TRPP2 and PRKCSH may lead to cyst formation in PCLD patients with PRKCSH mutations, and thereby account for the overlapping manifestations observed in PCLD and autosomal dominant polycystic kidney disease.
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Today in Basic Science/Genetics...keeping you current
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Similar incretin secretion in obese and non-obese Japanese subjects with type 2 diabetes
Biochemical and Biophysical Research Communications, 03/19/10
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Today in Gastroenterology...keeping you current
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