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New classification of the shared epitope in rheumatoid arthritis: Impact on the production of various anti-citrullinated protein antibodies
Rheumatology, 11/20/09

AuthorLastNameFI et al. – Our approach of comparing individual S allele carriers with X/X genotype patients allowed us to perform unequivocal analyses and demonstrate new associations. Thus, novel subgroups of RA could be identified with potential relevance for prognosis and therapy.

Methods

Serum and genomic DNA samples of 91 RA patients and 78 healthy controls obtained
Various ACPAs and IgM RF determined by ELISA. HLA-DRB1 genotyping and subtyping performed by PCR
Correlations between SE and ACPAs determined

Results

Not only S2 and S3P, but, to a lesser extent, S1 and S3D alleles also predisposed to anti-cyclic citrullinated peptide (CCP) production , with following hierarchy of association: S2+S3P > S1+S3D > X/X
Similar associations observed for anti-citrullinated vimentin
Anti-citrullinated fibrinogen (CF) exerted different association pattern with strongest correlation with S1 alleles
HLA-DRB1*15 alleles may represent special predisposing effect for anti-CF antibody production
RF production associated only with HLA-DRB1*0401 SE allele