Internal Med Medical News about Osteoporosis Bone signaling

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Bone signaling pathways and treatment of osteoporosis
Expert Review of Endocrinology & Metabolism, 11/10/09

Gogakos AI et al. – Bone turnover is a continuous process regulated by the coupled activities of osteocytes, osteoclasts and osteoblasts that maintain bone mass and strength. Osteoclastic bone resorption is regulated by the RANKL/osteoprotegerin/RANK pathway, while osteoblastic bone formation is controlled by canonical Wnt signaling. Antiresorptive bisphosphonates remain the mainstay of treatment but recombinant parathyroid hormone is increasingly being used as an anabolic agent. Nevertheless, these drugs are limited by patient compliance, efficacy and cost. Cathepsin K inhibitors and RANKL antibodies have been developed as new antiresorptive drugs, while short–acting calcilytics and antibodies to Dickkopf–1 and sclerostin are promising anabolics. The recent identification of adipocytes and duodenal enterochromaffin cells as novel regulators of bone mass represent exciting opportunities for future drug development.

Osteologix to Continue Development of Osteoporosis Drug
Internet Source, 10/21/09 Relevance Score: 70%

Lasofoxifene for the prevention and treatment of postmenopausal osteoporosis
Therapeutics and Clinical Risk Management, 10/16/09 Relevance Score: 69%

New Approach For Growing Bone To Fight Osteoporosis And Other Diseases
ScienceDaily, 10/08/09 Relevance Score: 69%

Assessing Fracture Risk and Effects of Osteoporosis Drugs: Bone Mineral Density and Beyond
American Journal of Medicine, 10/28/09 Relevance Score: 68%

Anthropometric and Skeletal Phenotype in Men with Idiopathic Osteoporosis and Their Sons Is Consistent with Deficient Estrogen Action during Maturation
Journal of Clinical Endocrinology and Metabolism, 10/12/09 Relevance Score: 68%