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See Latest ArticlesInsights into the pathogenesis of axial spondyloarthropathy based on gene expression profiles
Arthritis Research & Therapy, 11/10/09
Sharma MS et al. – Our observations are the first to implicate SPARC, SLPI, and NLRP2, a component of the innate immune system, in the pathogenesis of SpA. Our results also indicate a possible role for IL-1 and its receptors in SpA. In accord with the bone pathology component of SpA, we also found that expression levels of transcripts reflecting bone remodeling factors are also distinguishable in peripheral blood from patients with SpA versus controls. These results confirm some previously identified biomarkers implicated in the pathogenesis of SpA and also point to novel mediators in this disease.
Methods- High-density, human GeneChip(R) probe arrays (HG-U133 plus 2.0, Affymetrix, Inc.) used to profile mRNA of peripheral blood cells from 18 subjects with SpA
- 25 normal individuals
- Samples processed as 2 separate sets at different times (11 SpA + 12 control subjects in primary set (Set 1); 7 SpA+ 13 control subjects in the validation set (Set 2))
- Blood samples taken at time when patients not receiving systemic immunomodulatory therapy
- Differential expression defined as a 1.5-fold change with q value < 5%
- Gene ontology and pathway information also studied
- Signals from 134 probe sets (representing 95 known and 12 unknown gene transcripts) consistently different from controls in both Sets 1 and 2
- Included among these were transcripts for group of 20 genes, such as interleukin-1 (IL-1) receptors 1 and 2, Nod-like receptor family, pyrin domain containing 2 (NLRP2), secretory leukocyte peptidase inhibitor (SLPI), secreted protein acidic and rich in cysteine (SPARC), and triggering receptor expressed on myeloid cells 1 (TREM-1) that are clearly related to immune or inflammatory response and group of 4 transcripts that have strong role in bone remodeling
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Treatment of polymyalgia rheumatica
Archives of Internal Medicine, 11/10/09
Osteonecrosis of the jaw correlated to bisphosphonate therapy in non-oncologic patients: Clinicopathological features of 24 patients
Journal of Rheumatology, 11/09/09
Effect of biomagnetic therapy versus physiotherapy for treatment of knee osteoarthritis: A randomized controlled trial
Journal of Rehabilitation Medicine, 11/20/09
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