Internal Med Medical News about Diabetic Foot Infection Ertapenem

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The treatment of diabetic foot infections: focus on ertapenem
Vascular Health and Risk Management, 11/09/09

Edmonds M – Clinically, 3 distinct stages of diabetic foot infection may be recognized: localized infection, spreading infection and severe infection. Each of these presentations may be complicated by osteomyelitis. Infection can be caused by Gram–positive aerobic, and Gramnegative aerobic and anaerobic bacteria, singly or in combination. Localized infections with limited cellulitis can generally be treated with oral antibiotics on an outpatient basis. Spreading infection should be treated with systemic antibiotics. Severe deep infections need urgent admission to hospital for wide–spectrum intravenous antibiotics. Clinical and microbiological response rates have been similar in trials of various antibiotics and no single agent or combination has emerged as most effective. Recently, clinical and microbiological outcomes for patients treated with ertapenem were equivalent to those for patients treated with piperacillin/tazobactam. It is also important to judge the need for debridement and surgery, to assess the arterial supply to the foot and consider revascularization either by angioplasty or bypass if the foot is ischemic.

Accounting for the Development of Antibacterial Resistance in the Cost Effectiveness of Ertapenem versus Piperacillin/Tazobactam in the Treatment of Diabetic Foot Infections in the UK
PharmacoEconomics, 11/17/09 Relevance Score: 88%

Exploring the complex care of the diabetic foot ulcer
JAAPA, 10/30/09 Relevance Score: 82%

Hyperbaric oxygen therapy as an anti-infective agent
Expert Review of Anti-infective Therapy, 10/21/09 Relevance Score: 80%

Diabetic Foot Infections
Journal of the American Podiatric Medical Association, 10/05/09 Relevance Score: 80%

Evaluation of the bacterial diversity among and within individual venous leg ulcers using bacterial tag-encoded FLX and Titanium amplicon pyrosequencing and metagenomic approaches
BMC Microbiology, 10/30/09 Relevance Score: 78%