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The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation
Diabetologia - Clinical and Experimental Diabetes and Metabolism, 11/09/09

Kolb H et al. – The recent major increase in the global incidence of type 2 diabetes suggests that most cases of this disease are caused by changes in environment and lifestyle. All major risk factors for type 2 diabetes (overnutrition, low dietary fibre, sedentary lifestyle, sleep deprivation and depression) have been found to induce local or systemic low–grade inflammation that is usually transient or milder in individuals not at risk for type 2 diabetes. By contrast, inflammatory responses to lifestyle factors are more pronounced and prolonged in individuals at risk of type 2 diabetes and appear to occur also in the pancreatic islets. Chronic low–grade inflammation will eventually lead to overt diabetes if counter–regulatory circuits to inflammation and metabolic stress are compromised because of a genetic and/or epigenetic predisposition. Hence, it is not the lifestyle change per se but a deficient counter–regulatory response in predisposed individuals which is crucial to disease pathogenesis. Novel approaches of intervention may target these deficient defence mechanisms.

Hepatic fat and inflammation in type 2 diabetes mellitus
Metabolism-Clinical and Experimental, 10/26/09 Relevance Score: 82%

Value of C-reactive protein and IL-6 measurements in type 1 diabetes mellitus
Archives of Medical Science, 11/02/09 Relevance Score: 81%

Gender differences in adiponectin and low-grade inflammation among individuals with normal glucose tolerance, prediabetes, and type 2 diabetes
Gender Medicine, 10/21/09 Relevance Score: 80%

Effect of pioglitazone on systemic inflammation is independent of metabolic control and cardiac autonomic function in patients with type 2 diabetes
Acta Diabetologia, 10/08/09 Relevance Score: 80%

Long- but not short-term multifactorial intervention with focus on exercise training improves coronary endothelial dysfunction in diabetes mellitus type 2 and coronary artery disease
European Heart Journal, 10/01/09 Relevance Score: 79%