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Blood dendritic cells in systemic lupus erythematosus exhibit altered activation state and chemokine receptor function
Annals of Rheumatic Diseases, 11/09/09

Gerl V et al. – The phenotypic and migratory disturbances observed in SLE blood DCs could result in altered distribution of DCs in peripheral tissues, contributing to dysregulated immune responses and autoimmunity.

• Plasmacytoid DCs (pDCs), myeloid DCs (mDCs) and monocytes from SLE patients, healthy volunteers, and healthy volunteers immunized with tetanus/diphtheria examined by flow cytometry for expression of subset specific antigens (BDCA-2, CD11c, CD14, HLA-DR), activation/maturation markers (CD83, CD86, CD40, BLyS) and chemokine receptors (CCR1, CCR5, CCR7, ChemR23)
• Migratory capacity to chemokine receptors investigated in vitro using chemokines RANTES, CCL19 and chemerin

• SLE monocytes and myeloid DCs had higher CD86 and BLyS expression levels
• ChemR23 expression lower in SLE plasmacytoid and myeloid DCs (p = 0.03). Basal (p= 0.004) and CCL19-specific migration levels (p=0.004) were higher in SLE plasmacytoid DCs
• Altered DC function in SLE had no correlative changes in chemokine receptor expression whereas immunization-induced blood DC migration patterns in healthy donors accompanied by changes in chemokine receptor expression

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