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See Latest ArticlesiTRAQ-based proteomic identification of leucine rich alpha 2 glycoprotein (LRG) as a novel inflammatory biomarker in autoimmune diseases
Annals of Rheumatic Diseases, 11/09/09
Satoshi Serada et al. – LRG represents a novel serum biomarker for monitoring disease activity during therapy in autoimmune patients, particularly useful in patients with active disease but normal CRP levels. Therefore, serum LRG potentially surrogate for CRP.
Methods- Sera obtained from RA patients before and after anti-TNF therapy were analyzed by quantitative proteomics using isobaric tags for relative and absolute quantitation (iTRAQ) and further validated by ELISA.
- 326 proteins identified by proteomic analysis
- Identified increased serum levels of leucine rich alpha 2 glycoprotein (LRG) in RA patients before therapy
- ELISA analysis revealed serum LRG concentrations significantly elevated in RA patients compared to healthy controls and decreased after anti-TNF therapy
- Serum LRG concentrations correlated with serum C-reactive protein (CRP) levels in patients with RA, Behcet’s disease and Crohn’s disease (CD) and correlated with disease activity in RA and CD
- In subpopulation of active CD patients with normal CRP levels, serum LRG concentrations elevated
- Serum LRG concentrations were significantly higher in CD patients refractory to anti-TNF therapy compared to those responsive to therapy
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