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Effects of dehydroepiandrosterone on fatigue and well-being in women with quiescent systemic lupus erythematosus. A randomized controlled trial
Annals of Rheumatic Diseases, 11/10/09

Hartkamp A et al. – Our trial does not indicate an effect of daily 200 mg oral DHEA on fatigue and well-being and therefore DHEA treatment is not recommended in unselected female patients with quiescent SLE.

Methods

Double-blind, randomized, placebo-controlled study
60 female patients with inactive SLE received 200 mg oral DHEA or placebo
Primary outcome measures general fatigue, depressive mood, mental well-being, and physical functioning
Assessments were before treatment, after 3, 6, and 12 months on medication, and 6 months after cessation of treatment

Results

Patients from both DHEA and placebo group improved on general fatigue and mental well-being
No differential effect of DHEA
Belief to have used DHEA was a stronger predictor for improvement of general fatigue than the actual use of DHEA