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Metabolic syndrome and risk of subsequent colorectal cancer
World Journal of Gastroenterology, 11/09/09

Pais R et al. – The physiopathological mechanism that links metabolic syndrome and colorectal cancer is mostly related to abdominal obesity and insulin resistance. Population and experimental studies demonstrated that hyperinsulinemia, elevated C–peptide, elevated body mass index, high levels of insulin growth factor–1, low levels of insulin growth factor binding protein–3, high leptin levels and low adiponectin levels are all involved in carcinogenesis. Understanding the pathological mechanism that links metabolic syndrome and its components to carcinogenesis has a major clinical significance and may have profound health benefits on a number of diseases including cancer, which represents a major cause of mortality and morbidity in these societies.