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Tracy Hampton, PhD
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Casopitant improves the quality of life in patients receiving highly emetogenic chemotherapy
Supportive Care in Cancer, 11/06/09
Gridelli C et al. – The addition of casopitant to ondansetron and dexamethasone in patients receiving HEC was significantly more effective in reducing the impact of nausea and vomiting on all daily life activities as assessed by the FLIE compared with ondansetron/dexamethasone dual therapy.
Methods- Multicenter, double-blind, randomized, placebo-controlled, add-on trial (N?=?810)
- Patients randomized to intravenous (IV) ondansetron/dexamethasone alone (control) or in combination with either single 150-mg oral dose of casopitant or 3-day IV/oral casopitant
- Quality of life assessed as impact of nausea and vomiting on daily life using Functional Living Index Emesis (FLIE) questionnaire
- Patients completed FLIE questionnaire at baseline prior to receiving chemotherapy and after completion of first cycle of HEC
- Patients in single oral dose and 3-day IV/oral casopitant groups scored higher mean total FLIE scores than patients in control group , indicating that casopitant patients experienced less impact from nausea and vomiting on daily life
- Overall absolute difference in proportion of patients reporting CINV with no impact on daily life between single oral casopitant group and control group was 13%
- Difference between 3-day IV/oral casopitant group and control group was 14%
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