Internal Med Medical News about antiplatelet agents

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New antiplatelet agents: Why they are needed
European Journal of Internal Medicine , 11/09/09

Franchini M et al. – The limitations of the currently available antiplatelet agents have triggered the development of newer drugs. In this review we summarize the mechanisms of actions and results of current clinical trials of novel antiplatelet agents. These include prasugrel, a thienopyridine prodrug which has a mechanism similar to that of clopidogrel but superior pharmacokinetic features; ticagrelor, a non–thienopyridine that binds reversibly to the platelet P2Y12 receptor; cangrelor, an intravenously administered analog of ticagrelor; the thrombin receptor antagonist SCH 53048; and terutroban (S18886), a thromboxane A2 receptor inhibitor.

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Role of Antiplatelet Agents in Hematoma Expansion During The Acute Period of Intracerebral Hemorrhage
Neurocritical Care, 10/23/09 Relevance Score: 66%

Oral Antiplatelet Therapy for Acute and Chronic Management of NSTE ACS: Residual Ischemic Risk and Opportunities for Improvement
Cardiovascular Drugs and Therapy, 11/17/09 Relevance Score: 65%

Antithrombotic and antiplatelet activities of fenofibrate, a lipid-lowering drug
Atherosclerosis, 10/07/09 Relevance Score: 65%

Types of Thromboembolic Complications in Coil Embolization for Intracerebral Aneurysms and Management
Journal of Korean Neurosurgical Society, 11/04/09 Relevance Score: 64%

Comparison of prasugrel and clopidogrel in patients with acute coronary syndrome undergoing percutaneous coronary intervention
Vascular Health and Risk Management, 10/22/09 Relevance Score: 64%