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Anti-cyclic citrullinated peptide antibodies as a discriminating marker between rheumatoid arthritis and chronic hepatitis C-related polyarthropathy
Rheumatology International, 11/05/09

Ezzat WM et al. –Anti-CCP antibodies are reliable laboratory markers to differentiate between RA and HCV-related polyarthropathy.

• Anti-cyclic citrullinated peptide (CCP) antibodies and RF determined in sera of 30 patients with RA and 22 patients with HCV-related polyarthropathy

• Anti-CCP antibodies positive in 83.3% of patients with RA and 4.5% in patients with HCV and polyarthropathy
• RF positive in 90% of RA patients and 81.1% of HCV patients with polyarthropathy
• Anti-CCP antibodies showed higher specificity for RA compared with RF (95.4 vs. 18.2%)
• Sensitivity of anti-CCP comparable to that of RF (83.3 vs. 90%)

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