Internal Med Medical News about Sodium Bicarbonate Contrast-Induced Nephropathy

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Systematic Review: Sodium Bicarbonate Treatment Regimens for the Prevention of Contrast-Induced Nephropathy
Annals of Internal Medicine, 11/03/09

Zoungas S et al. – This review of 9 published and 14 unpublished trials of sodium bicarbonate suggests that the effect of this agent has been overestimated. Unpublished trials found smaller effects than published trials, and formal testing confirmed publication bias. Sodium bicarbonate is probably less effective at preventing contrast–induced nephropathy than is currently thought. Routine use of sodium bicarbonate for prevention of contrast–induced nephropathy is therefore premature.