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Citrulline dependence of anti-cyclic citrullinated peptide antibodies in systemic lupus erythematosus as a marker of deforming/erosive arthritis
Journal of Rheumatology, 11/06/09
Kakumanu P et al. – Conclusion Citrulline dependence or high levels (> 10) of anti-CCP were common in SLE patients with deforming/erosive arthritis, while most anti-CCP in SLE patients was citrulline-independent. This may be useful in identifying a subset of SLE patients with high risk for development of deforming/erosive arthritis.
Methods- IgG anti-CCP compared by ELISA to anti-CAP in sera from patients with SLE (n = 335) and RA (n = 47) and healthy controls (n = 35)
- SLE patients were divided into 5 groups based on their joint involvement: subset I: deforming/erosive arthritis (n = 20); II: arthritis fulfilling (or likely fulfilling) American College of Rheumatology criteria for RA but without erosions (n = 18); III: joint swelling but not fulfilling RA criteria (n = 39); IV: arthritis without documented joint swelling (n = 194); and V: no arthritis (n = 58)
- Anti-CCP (> 1.7 units) found in 68% (32/47) of patients with RA and 17% (55/329) of those with SLE
- More common in SLE patients with deforming/erosive arthritis (38%)
- High anti-CCP (> 10 units) was found in RA (26%) and deforming/erosive SLE (12%)
- High anti- CCP/CAP ratios (> 2, indicating a selectivity to CCP) were found in 91% of anti-CCP-positive RA and 50% of anti-CCP-positive SLE patients with deforming/erosive arthritis
- Patients from subset II did not have high anti-CCP/CAP
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Effect of biomagnetic therapy versus physiotherapy for treatment of knee osteoarthritis: A randomized controlled trial
Journal of Rehabilitation Medicine, 11/20/09
Prediction of vertebral fractures is specific for gender and site of bone mineral density measurement
Journal of Rheumatology, 11/20/09
Baseline glucocorticoid dose and bone mineral density response with teriparatide or alendronate therapy in patients with glucocorticoid-induced osteoporosis
Journal of Rheumatology, 11/20/09
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