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Adherence to Screening for Hepatocellular Carcinoma Among Patients with Cirrhosis or Chronic Hepatitis B in a Community Setting
Digestive Diseases and Sciences, 11/02/09

Wong CR et al. – Since more frequent clinic visits is a strong independent predictor of improved screening adherence, regular routine clinic visits may help improve adherence to HCC screening, which may also lead to improved clinical outcomes.

Exclusive Author Commentary
Carrie R. Wong, 11/04/09

In our cohort of 557 consecutive patients with cirrhosis or chronic hepatitis B without cirrhosis in two community gastroenterology clinics with a median of 61 months of follow-up, we discovered that 40.6% of our cohort received poor screening (less often than every 12 months) or no screening for hepatocellular carcinoma (HCC). Furthermore, patients who had chronic hepatitis B without cirrhosis had worse screening than those with cirrhosis. These findings reveal public health implications as our study also showed associations between the quality of adherence to HCC screening and to eligibility to curative surgery and to five-year HCC survival. Per multivariate logistic analysis, more frequent clinic visits per year was the only significant independent predictor for HCC screening at least every 12 months. Our results suggest that regular routine clinic visits may help improve adherence to HCC screening, leading to improved clinical outcomes for patients with cirrhosis or chronic hepatitis B without cirrhosis.

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Rheumatology International, 11/13/09 Relevance Score: 69%

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Hepatitis B Virus Resistance to Nucleostide Analogues
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