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Inhaled Mannitol Improves the Hydration and Surface properties of Sputum in patients with Cystic Fibrosis
Chest, 11/03/09

Daviskas E et al. – Treatment with inhaled mannitol over 2 weeks improved the hydration and surface properties of sputum in patients with CF. This effect was sustained and correlated with airway function changes.

Exclusive Author Commentary
Dr Evangelia Daviskas, 11/07/09

Patients with Cystic Fibrosis (CF) have dehydrated mucus that sticks to the airway surface and fails to be cleared by ciliary and cough action. Dehydrated mucus accumulates in the airways and thus contributes to progression of the disease. Therefore, a major goal in the treatment of CF is to improve and maintain good clearance of the airway mucus. Inhaled mannitol has been shown to improve clearance of mucus, lung function and quality of life in patients with CF. The current study has elucidated some of the mechanisms whereby regular treatment with inhaled mannitol may have significant and sustained clinical benefits in these patients.