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Juliard JM – The rational use of these stents requires choosing lesions at high–risk for restenosis (long lesions on small vessels, for example) in patients who can be monitored for at least one year and a dual antiplatelet therapy, which sudden discontinuation of which is a strong and independent risk factor for acute stent thrombosis with sometimes fatal consequences. These are prerequisite conditions for optimizing both the risk/benefit and cost/benefit ratios of DES. The development of full biodegradable DES stents and more effective and reproducible antiplatelet therapy is advancing to make these procedures even safer and more effective.

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