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Inflammatory mediators and premature coronary atherosclerosis in rheumatoid arthritis
Arthritis Care and Research , 11/03/09

Rho YH et al. – TNF&alpha and IL-6 are significantly associated with the severity of subclinical atherosclerosis, independent of Framingham risk score, in RA.

• Clinical variables, concentrations of inflammatory mediators, and coronary artery calcification measured in 169 patients with RA and 92 control subjects
• Differences in concentrations of inflammatory mediators were compared using median quantile regression
• Relationship of inflammatory mediators with severity of coronary calcification in RA and control subjects examined using proportional odds logistic regression, allowing for interaction with disease status
• Models were adjusted for traditional cardiovascular risk factors

• Median serum concentrations of IL-6, SAA, ICAM-1, E-selectin, TNF&alpha , and MPO and peripheral blood neutrophil count were higher in patients with RA than controls , independent of Framingham risk score and diabetes mellitus (DM). IL-6 (main effect odds ratio [OR] 1.72; 95% confidence interval [95% CI] 1.12, 2.66) and TNF&alpha concentrations were significantly associated with higher amounts of coronary calcium, independent of Framingham risk score and DM, and such main effects significantly differed from controls

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