Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. Recommendations on the use of 18F-FDG PET in oncology 3. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer 4. AHA Guidelines on Cardiac CT for Assessing Coronary Artery Disease 5. Rapid correction of low vitamin D status in nursing home residents
Top Ten Searches
etanercept hypertension chf antiphospholipid fibrosis mrsa scid renal cell rickets counterpulsationYour Article Summary
See Latest ArticlesCartilage loss occurs in the same subregions as subchondral bone attrition: A within-knee subregion-matched approach from the multicenter osteoarthritis study
Arthritis Care and Research , 11/05/09
Neogi T et al. SBA is strongly associated with cartilage loss within the same subregion of a knee. SBA may directly influence overlying cartilage loss or serve as a marker of an area undergoing great compressive stress and in which cartilage loss is inevitable.
Methods- Multicenter Osteoarthritis Study is cohort of individuals who have or are at high risk for knee OA
- At baseline and 30 months, participants' knee MRIs graded using the Whole-Organ Magnetic Resonance Imaging Score in 10 subregions of the tibiofemoral joint for cartilage morphology and SBA
- Analyses conducted within a knee to eliminate between-person confounding, using an M:N (cases:controls) matched case-control approach with 10 subregions of person's knee forming matched set
- Cases within a knee were defined as subregions with cartilage loss, while controls were subregions in that same knee without cartilage loss
- Evaluated the association of cartilage loss over 30 months with presence of baseline SBA in same subregion within that knee using conditional logistic regression
- SBA associated with odds ratio of 7.5 (95% confidence interval 5.6-9.9) for cartilage loss in same subregion compared with subregions without any baseline SBA in sample of 459 knees
- 64% women, mean age 63 y
- Mean BMI of 30.5 kg/m2
Today in Rheumatology...keeping you current
Receive free subspecialty "5-minute updates" via email
Is osteoarthritis a heterogeneous disease that can be stratified into subsets?
Clinical Rheumatology, 11/24/09
Low plasma levels of monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF &alpha), and vascular endothelial growth factor (VEGF) in patients with alpha1-antitrypsin deficiency-related fibromyalgia
Clinical Rheumatology, 11/24/09
Lipid peroxidation, glutathione, vitamin E, and antioxidant enzymes in synovial fluid from patients with osteoarthritis
International Journal of Rheumatic Diseases, 11/24/09
Sponsor
Article Search
Sponsor
Sponsor