Internal Med Medical News about Body Composition Insulin Resistance

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Evolution, body composition, insulin receptor competition, and insulin resistance
Preventive Medicine, 11/02/09

Eaton SB et al. – Average human adiposity and sarcopenia have attained unprecedented levels and the resultantly abnormal body composition distorts insulin receptor balance. Compared to evolutionary norms we now have too many adipocyte insulin receptors (in adipose tissue and liver) and too few myocyte insulin receptors. The body's insulin receptors can be conceptualized as competing for insulin molecules released from the pancreas. When an insulin molecule docks on an adipocyte receptor, substantially fewer glucose molecules are cleared from the blood than when an insulin molecule docks on a myocyte insulin receptor. Populational insulin receptor imbalance would seem to parallel the secular rise in insulin resistance and offers an attractive pathophysiological explanation for the accompanying type 2 diabetes epidemic. An evolutionary perspective regarding body composition, insulin receptor imbalance, and the consequent impact on carbohydrate metabolism should enhance public acceptance of recommendations to increase physical activity.

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Reduction of Skeletal Muscle, Especially in Lower Limbs, in Japanese Type 2 Diabetic Patients With Insulin Resistance and Cardiovascular Risk Factors
Metabolic Syndrome and Related Disorders, 11/11/09 Relevance Score: 87%

Fetuin-A and Change in Body Composition in Older Persons
Journal of Clinical Endocrinology and Metabolism, 10/15/09 Relevance Score: 87%

Ethnic Variation in Fat and Lean Body Mass and the Association with Insulin Resistance
Journal of Clinical Endocrinology and Metabolism, 10/15/09 Relevance Score: 81%

Roles of the lipid peroxidation product 4-hydroxynonenal in obesity, the metabolic syndrome, and associated vascular and neurodegenerative disorders
Experimental Gerontology, 11/12/09 Relevance Score: 80%

Gender-Specific Prevalences of Fatty Liver in Obese Children and Adolescents: Roles of Body Fat Distribution, Sex Steroids, and Insulin Resistance
Journal of Clinical Endocrinology and Metabolism, 10/12/09 Relevance Score: 80%