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Karapolat S et al. – The significant increases that occurred in tumor necrosis factor–? level as a result of intra–arterial application of heparin can be postulated to be one of the results of angiogenesis induced by the heparin in ischemic extremities. This might delay the formation of a necrosis in ischemic extremities, depending on the increased angiogenesis response by means of intra–arterial heparin application and may result in extended vitality of an extremity.


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