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See Latest ArticlesUse of bisphosphonates and raloxifene and risk of deep venous thromboembolism and pulmonary embolism
Osteoporosis International, 10/30/09
Vestergaard P et al. – Bisphosphonates seem associated with an increased risk of DVT/PE. However, the association does not seem to be causal.
Methods- Nationwide register-based cohort study from Denmark with all users of bisphosphonates and other drugs against osteoporosis between 1996 and 2006 as cases and three age- and gender-matched controls from the general population
- Before start of drug against osteoporosis, increased risk of DVT/PE present in crude analysis for alendronate, etidronate, and risedronate
- Upon adjustment, increase in risk disappeared
- Before start of raloxifene, decreased risk of DVT/PE present (odds ratio (OR)?=?0.53, 95% confidence interval (CI), 0.39–0.71)
- After start of drug, alendronate , clodronate , and etidronate (HR?=?1–37, 95% CI, 1.23–1.51) were all associated with an increased risk of DVT/PE, while raloxifene was only borderline, significantly associated with risk of DVT/PE
- No dose–reponse relationship present except for alendronate, where risk was inversely associated with dose, i.e., risk of DVT/PE decreased with increasing average daily dose
- Alendronate and raloxifene carried same risk for DVT/PE
Today in Clinical Pharmacology...keeping you current
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Novel Therapies for Pemphigus Vulgaris: An Overview
Drugs & Aging, 09/21/09
New Anticoagulants in Atrial Fibrillation
Seminars in Thrombosis and Hemostasis, 10/02/09
Antithrombotic medication for stroke prevention
Expert Review of Cardiovascular Therapy , 10/20/09
Today in Pulmonology...keeping you current
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An Umbrella Review: Corticosteroid Therapy for Adults with Acute Asthma
American Journal of Medicine, 10/27/09
Magnesium sulphate in the treatment of acute asthma: evaluation of current practice in adult emergency departments
Emergency Medicine Journal, 10/27/09
Management of H1N1 influenza virus respiratory syndrome
Minerva Anestesiologica, 11/11/09
Today in Vascular Medicine...keeping you current
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Antithrombotic medication for stroke prevention
Expert Review of Cardiovascular Therapy , 10/20/09
Vitamin D and cardiovascular disease
Current Atherosclerosis Reports, 11/12/09
Effectiveness of Two-Year Clopidogrel + Aspirin in Abolishing the Risk of Very Late Thrombosis After Drug-Eluting Stent Implantation (from the TYCOON [Two-Year ClOpidOgrel Need] Study)
The American Journal of Cardiology, 11/05/09
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