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Appraisal of antinociceptive and anti-inflammatory potential of extract and fractions from the leaves of Torreya grandis Fort Ex. Lindl
Journal of Ethnopharmacology , 10/28/09

Saeed MK et al. – It was found that T. grandis extract and fractions at the doses of (100 and 200 mg/kg, i.g.) were significantly attenuated the writhing responses induced by acetic acid and second phase of pain response induced by sub plantar injection of formalin in mice. In addition, these extract and fractions inhibiting the formaldehyde–induced arthritis as well as xylene–induces edema prolifically. From acute oral toxicity studies no mortality was pragmatic even at highest dose (2500 mg/kg, i.g.). Furthermore, these phytochemical studies indicated that the aq. ethanolic extract of leaves contains alkaloids, flavonoids, tannins, terpenoids and saponins. The results provide justification for the folkloric uses of T. grandis in the treatment of analgesic and inflammatory–based diseases across the China.