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Vanpouille C et al. – Recent studies have shown that although ACV therapy does not prevent HIV–1 transmission, it decreases plasma, genital, rectal, and seminal HIV–1 RNA levels. The decrease of HIV–1 load has been believed to be the result of an indirect mechanism and explained by reduction of HSV–2–mediated inflammation. The discovery of the direct inhibitory activity of ACV on HIV–1 reverse transcriptase brings new insights into the interpretation of these results. Also, it is important to understand why HSV–2–suppressive therapy with ACV did not reduce HIV–1 acquisition/transmission.

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