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See Latest ArticlesGene expression of NMDA receptor subunits in the cerebellum of elderly patients with schizophrenia
European Archives of Psychiatry and Clinical Neuroscience, 10/29/09
Schmitt A et al. – Increased NR2D expression results in a hyperexcitable NMDA receptor suggesting an adaptive effect due to receptor hypofunction. The decreased NR2C expression in NRG1 risk variant may cause a deficit in NMDA receptor function. This supports the hypothesis of an abnormal glutamatergic neurotransmission in the right cerebellum in the pathophysiology of schizophrenia.
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