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See Latest ArticlesArterial stiffness and cumulative inflammatory burden in rheumatoid arthritis: A dose-response relationship independent of established cardiovascular risk factors
Rheumatology, 10/28/09
Crilly MA et al. – To quantify the relationship between arterial stiffness and cumulative inflammatory burden in patients with RA. In RA patients free of overt arterial disease, a dose–response relationship exists between cumulative inflammatory burden and arterial stiffness. This relationship is independent of established CV risk factors.
Methods- Recruited RA patients without overt arterial disease aged 40–65 years, attending hospital rheumatology outpatient clinics
- Standardized research nurse assessment included blood pressure (BP), pulse wave analysis (PWA, SphygmoCor), BMI, fasting blood sample (lipids, glucose, RF and ESR), patient questionnaire (smoking, alcohol, diet, exercise, family history of premature coronary heart disease and Stanford HAQ), current medication and medical record review
- Cumulative inflammatory burden measured as ESR area-under-the-curve (ESR-years) extracted from medical records
- Arterial stiffness measured using PWA
- Multiple linear regression was used to adjust for age, sex and nine other cardiovascular risk factors
- Recruited 114 RA patients (mean age 54 years, female 81%, current DMARD 90%, current NSAID 70%, ACR criteria 56%) comprising 1040 RA person-years
- Cholesterol, glucose and BMI were similar in women and men
- Women had longer duration of arthritis (10 vs 7 years) and were more likely to be seropositive (85 vs 71%)
- BP, smoking and alcohol consumption lower for women
- Fully adjusted analysis restricted to women the increase was 0.43
Today in Rheumatology...keeping you current
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Effect of alendronate on bone metabolic indices and bone mineral density in patients treated with high-dose glucocorticoid: A prospective study
Osteoporosis International, 11/25/09
Treatment of osteoporosis: Recognizing and managing cutaneous adverse reactions and drug-induced hypersensitivity
Osteoporosis International, 11/25/09
Prevalent vertebral deformity independently increases incident vertebral fracture risk in middle-aged and elderly Japanese women: The Japanese Population-based Osteoporosis (JPOS) Cohort Study
Osteoporosis International, 11/25/09
Today in Vascular Medicine...keeping you current
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The prognostic impact of general and abdominal obesity in peripheral arterial disease
International Journal of Obesity, 11/25/09
Prospective analysis of risk factors and distribution of venous thromboembolism in the population-based Malmo Thrombophilia Study (MATS)
Thrombosis Research, 11/25/09
Effect of cilnidipine vs losartan on cerebral blood flow in hypertensive patients with a history of ischemic stroke: a randomized controlled trial
Acta Neurologica Scandinavica, 11/25/09
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