Internal Med Medical News about Migraine Disorders 5-HTT gene

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Single Nucleotide Polymorphisms of the Serotonin Transporter Gene in Migraine – An Association Study
Headache: The Journal of Head and Face Pain, 10/26/09

Bayerer B et al. – The authors report a case–control study with 251 unrelated migraine patients and 192 unrelated healthy controls to evaluate an association between the polymorphisms of the 5–HT transporter (5–HTT) gene rs2066713 and rs1979572 and different migraine phenotypes. The authors found a genetic association for the A allele of rs1979572 for migraine with aura (MA) especially in women as well as a significant lower prevalence for MA for carrier of the A allele of rs2066713 in women. These findings support previous results suggesting that the 5–HTT gene is involved in the polygenic etiology of MA. These data further suggest that women are more likely to be clinically affected by mutations in the 5–HTT gene than men.