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Oelke M et al. – The combination of an [alpha]–blocker plus a muscarinic receptor antagonist is more effective than single drugs used alone. Especially in men with larger prostates, 5?–reductase inhibitors can decrease LUTS and the probability of acute urinary retention as well as need for prostate surgery. The combination of ?–blocker plus 5?–reductase inhibitor can reduce LUTS and disease progression more effectively than single drugs.

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