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Intentional weight loss and risk of lymphohematopoietic cancers
Cancer Causes and Control, 10/27/09

De Roos AJ et al. – It was hypothesized that intentional weight loss may be associated with development of lymphohematopoietic cancers, based on observations of immune suppression following weight loss in short-term studies. Further assessment of intentional weight loss as a possible risk factor for lymphomas may provide insight into the etiology of these cancers.

• At baseline of Women’s Health Initiative Observational Study (1994–1998), participants reported information about intentional weight loss episodes in past 20 years
• Estimated hazard ratios (HRs) and 95% confidence intervals (CIs) among 81,219 women for associations between past intentional weight loss and risk of developing non-Hodgkin lymphoma (NHL), leukemia, and multiple myeloma during an average 9.9 years of follow-up

• Risk of NHL associated with having lost a large maximum amount of weight (≥ 50 pounds, HR = 1.68, 95% CI 1.13–2.50)
• NHL risk also varied by frequency of intentional weight loss; women had increased risk if they lost 50 pounds or more ≥ 3 times or 20–49 pounds ≥ 3 times
• No risk associated with smaller amounts of weight loss (10–19 pounds ≥ 3 times, HR = 0.78, 95% CI 0.46–1.33)

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