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Loss of Tsc1, but not Pten, in renal tubular cells causes polycystic kidney disease by activating mTORC1
Human Molecular Genetics, 11/03/09
Zhou J et al. – Disruption of Pten, an upstream regulator of TSC1/TSC2, in the same cells, does not lead to PKD seemingly due to limited activation of mTORC1, suggesting that PTEN may not be a major upstream regulator of TSC/mTORC1 during early postnatal kidney development.
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Today in Basic Science/Genetics...keeping you current
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Multilocus methylation analysis in a large cohort of 11p15-related foetal growth disorders (Russell Silver and Beckwith Wiedemann syndromes) reveals simultaneous loss of methylation at paternal and maternal imprinted loci
Human Molecular Genetics, 11/25/09
Adenosine deamination in human transcripts generates novel microRNA binding sites
Human Molecular Genetics, 11/25/09
Skeletal dysplasias due to filamin A mutations result from a gain-of-function mechanism distinct from allelic neurological disorders
Human Molecular Genetics, 11/25/09
Today in Nephrology/Urology...keeping you current
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Prospective studies of dietary alpha-linolenic acid intake and prostate cancer risk: a meta-analysis
Cancer Causes and Control, 11/25/09
Measurement of kidney perfusion by magnetic resonance imaging: comparison of MRI with arterial spin labeling to para-aminohippuric acid plasma clearance in male subjects with metabolic syndrome
Nephrology Dialysis Transplantation, 11/25/09
25-Hydroxyvitamin D Levels, Race, and the Progression of Kidney Disease
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