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The endogenous modulators of Ca2+–Mg2+-dependent ATPase in children with chronic kidney disease (CKD)
Nephrology Dialysis Transplantation, 11/09/09

Polak–Jonkisz D et al. – The intracellular Cai2+ homeostasis is disturbed in children with CKD and aggravates the deterioration of renal function as well. The reasons for the progressing increase of erythrocyte calcium concentration are multifactorial. Undoubtedly, the decreased PMCA activity, the calmodulin deficiency and the dysregulated CANP–CAST system are responsible for that phenomenon. The impact of many other biological modulators, creating a network defending the cell against the calcium accumulation, cannot be excluded.