Internal Med Medical News about Synovial Fluid

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TGF-beta inhibits IL-1beta-activated PAR-2 expression through multiple pathways in human primary synovial cells
BMC: Journal of Biomedical Science, 10/26/09

Tsai SH et al. – TGF–could prevent OA from progression with the anabolic ability to induce CTGF production to maintain extracellular matrix (ECM) integrity and to down regulate PAR–2 expression, and the anti–catabolic ability to induce Tissue inhibitors of metalloproteinase–3 (TIMP–3) production to inhibit MMPs leading to avoid PAR–2 over–expression. Because IL–1–induced PAR–2 expressed in hPSCs might play a significantly important role in early phase of OA, PAR–2 repression by exogenous TGF– or other agents might be an ideal therapeutic target to prevent OA from progression.

Terminal monosaccharide screening of synovial immunoglobulins G and A for the early detection of rheumatoid arthritis
Rheumatology International, 10/13/09 Relevance Score: 67%

Whole-body bone scintigraphy provides a measure of the total-body burden of osteoarthritis for the purpose of systemic biomarker validation
Arthritis & Rheumatism, 11/03/09 Relevance Score: 66%

The Prevalence and Pathogenesis of Synovial Cysts Within the Ligamentum Flavum in Patients With Lumbar Spinal Stenosis and Radiculopathy
Spine, 11/02/09 Relevance Score: 66%

Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase-1, and matrix metalloproteinase-13 expression in fibroblast-like synoviocytes more than proinflammatory mediators
Arthritis Research & Therapy, 11/11/09 Relevance Score: 65%

Phenotypic and functional characterization of switch memory B cells from patients with oligoarticular juvenile idiopathic arthritis
Arthritis Research & Therapy, 10/06/09 Relevance Score: 65%