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The influence of chemotherapy on bone mineral density, quantitative ultrasonometry and bone turnover in pre-menopausal women with breast cancer
European Journal of Cancer, 10/23/09

Hadji P et al. – Results confirm A/C’s deleterious influence on bone health in pre-menopausal women with BC and established QUS’s utility for monitoring bone effects.

Methods

106 women (BC=53, controls=53)
BMD (spine and hip), QUS (calcaneus and phalanges) and bone marker levels measured at baseline, 6 and 12months
Correlations between parameters determined by Spearman’s rho

Results

All BC patients became amenorrhoeic after chemotherapy and remained so for duration of treatment
BC patients had significant bone loss at all sites and significant increases in bone turnover
Significant correlations between BMD, QUS and bone markers

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