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See Latest ArticlesThe impact of comorbidity on physical function in patients with rheumatoid arthritis
Annals of Rheumatic Diseases, 10/22/09
Radner H et al. – Physical disability is worsening with increasing level of comorbidity, irrespective of disease activity.
Methods- Prospective cohort study
- Ascertained age adjusted Charlson comorbidity index (CCIA), as well as serial measurements of disease activity and functional disability (evaluated by the Health Assessment Questionnaire Disability Index, HAQ)
- 380 patients with established RA seen at outpatient clinic over one year (June 2007 to July 2008)
- Defined 4 patient groups with increasing levels of comorbidity
- Mean HAQ scores significantly different across these groups (0.67, 0.80, 1.24, 1.40, respectively) also when adjusted for disease activity, gender and disease duration in regression model (0.84, 0.88, 1.14, 1.48, respectively)
- CCIA effects on disability similar within different strata of disease activity, namely remission ; low disease activity ; and moderate to high disease activity and thus independent of disease activity
- Several sensitivity analyses, including use of SF-36, confirmed observations
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Site of psoriasis (scalp or intergluteal/perianal), >=3 affected sites, and nail dystrophy predicted psoriatic arthritis in incident psoriasis
Evidence-Based Medicine, 12/07/09
Both weight-bearing and non-weight-bearing exercise improved function in patients with knee osteoarthritis
Evidence-Based Medicine, 12/07/09
MLN3897 plus methotrexate in patients with rheumatoid arthritis: Safety, efficacy, pharmacokinetics, and pharmacodynamics of an oral CCR1 antagonist in a phase IIa, double-blind, placebo-controlled, randomized, proof-of-concept study
Arthritis & Rheumatism, 12/07/09
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