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See Latest ArticlesImmunologically silent cancer clone transmission from mother to offspring
Proceedings of the National Academy of Sciences of the United States of America, 10/22/09
Isoda T et al. – Maternal and infant cancer clones shared the same unique BCR–ABL1 genomic fusion sequence, indicating a shared, single–cell origin. Microsatellite markers in the infant cancer were all of maternal origin. Additionally, the infant, maternally–derived cancer cells had a major deletion on one copy of chromosome 6p that included deletion of HLA alleles that were not inherited by the infant (i.e., foreign to the infant), suggesting a possible mechanism for immune evasion.
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