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Putensen C et al. – This review of randomized trial evidence for low tidal volume and high PEEP ventilation on mortality of patients with ARDS or acute lung injury found that trials were limited in number but showed mortality benefits with lower versus higher tidal volume. High PEEP did not improve mortality in unselected patients but may help patients with life–threatening hypoxemia despite other interventions. Lower tidal volume ventilation strategies should be used for patients with ARDS or acute lung injury.

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